Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure

Ccr7 null mice are protected against diet-induced obesity via Ucp1 upregulation and enhanced energy expenditure

Abstract Background The chemokine receptor CCR7, expressed on various immune cells, is associated with cell migration and lympho-node homing. Mice lacking Ccr7 are protected from diet-induced obesity and subsequent insulin resistance. We evaluated the mechanism underlying these protective effects fr...

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Bibliographic Details
Main Authors: Tomomi Sano, Taiki Sanada, Yusuke Sotomaru, Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomoichiro Asano, Takashi Kanematsu, Fusanori Nishimura
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Nutrition & Metabolism
Subjects:
Obesity
Energy expenditure
Brown adipose tissue
Adipose tissue
Inflammation
Online Access:http://link.springer.com/article/10.1186/s12986-019-0372-5

Internet

http://link.springer.com/article/10.1186/s12986-019-0372-5

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