Decidual CD8+T cells exhibit both residency and tolerance signatures modulated by decidual stromal cells

Decidual CD8+T cells exhibit both residency and tolerance signatures modulated by decidual stromal cells

Abstract Background During early pregnancy, tolerance of the semi-allogeneic fetus necessitates comprehensive modifications of the maternal immune system. How decidual CD8+T (CD8+dT) cells balance maternal tolerance of the fetus with defense from invading pathogens remains undefined. Methods We inve...

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Bibliographic Details
Main Authors: Lu Liu, Xixi Huang, Chunfang Xu, Chunqin Chen, Weijie Zhao, Dajin Li, Liping Li, Li Wang, Meirong Du
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Translational Medicine
Subjects:
Maternal–fetal tolerance
CD8+T cell
Tissue resident memory cell
T cell exhaustion
Online Access:http://link.springer.com/article/10.1186/s12967-020-02371-3

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http://link.springer.com/article/10.1186/s12967-020-02371-3

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