Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors

Phenoxyacetohydrazide Schiff base analogs 1–28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 µM), 5 (IC50 = 9.47 ± 0.16 µM), 7 (IC50 = 14.7 ± 0.19 µM), 8 (IC50 = 15.4 ± 1.56 µM), 11 (IC50 = 19.6 ± 0.62 µM), 12 (IC50 = 30.7 ±...

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Bibliographic Details
Main Authors: Waqas Jamil, Shagufta Perveen, Syed Adnan Ali Shah, Muhammad Taha, Nor Hadiani Ismail, Shahnaz Perveen, Nida Ambreen, Khalid M. Khan, Muhammad I. Choudhary
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Molecules
Subjects:
phenoxyacetohydrazide
Schiff bases
β-glucouoronidase
glucuronosyl-O-bonds, D-saccharic acid-1,4-lactone
Online Access:http://www.mdpi.com/1420-3049/19/7/8788

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http://www.mdpi.com/1420-3049/19/7/8788

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