Oleuropein Attenuates Lipopolysaccharide-Induced Acute Kidney Injury In Vitro and In Vivo by Regulating Toll-Like Receptor 4 Dimerization

Oleuropein Attenuates Lipopolysaccharide-Induced Acute Kidney Injury In Vitro and In Vivo by Regulating Toll-Like Receptor 4 Dimerization

Acute kidney injury (AKI) is a common critical illness that involves multiple systems and multiple organs with a rapid decline in kidney function over short period. It has a high mortality rate and presents a great treatment challenge for physicians. Oleuropein, the main active constituent of Ilex p...

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Bibliographic Details
Main Authors: Yushun Cui, Hongwei Gao, Shan Han, Renyikun Yuan, Jia He, Youqiong Zhuo, Yu-Lin Feng, Meiwen Tang, Jianfang Feng, Shilin Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Pharmacology
Subjects:
oleuropein
acute kidney injury
TLR4
NF-κB
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.617314/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.617314/full

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