Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.

Baclofen, a GABABR agonist, ameliorates immune-complex mediated acute lung injury by modulating pro-inflammatory mediators.

Immune-complexes play an important role in the inflammatory diseases of the lung. Neutrophil activation mediates immune-complex (IC) deposition-induced acute lung injury (ALI). Components of gamma amino butyric acid (GABA) signaling, including GABA B receptor 2 (GABABR2), GAD65/67 and the GABA trans...

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Bibliographic Details
Main Authors: Shunying Jin, Michael L Merchant, Jeffrey D Ritzenthaler, Kenneth R McLeish, Eleanor D Lederer, Edilson Torres-Gonzalez, Mostafa Fraig, Michelle T Barati, Alex B Lentsch, Jesse Roman, Jon B Klein, Madhavi J Rane
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4388838?pdf=render

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http://europepmc.org/articles/PMC4388838?pdf=render

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