Nanoparticle-Mediated Delivery of Emodin via Colonic Irrigation Attenuates Renal Injury in 5/6 Nephrectomized Rats

Nanoparticle-Mediated Delivery of Emodin via Colonic Irrigation Attenuates Renal Injury in 5/6 Nephrectomized Rats

Our previous study showed that emodin enema modulates gut microbiota and delays CKD progression. However, the poor solubility, limited colonic irrigation retention time, and inadequate colon adhesion of emodin hinder its clinical application. Based on the deficiencies of emodin, we prepared monometh...

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Bibliographic Details
Main Authors: Zhaoyu Lu, Chunlan Ji, Xuewen Luo, Yong Lan, Lijuan Han, Yang Chen, Xusheng Liu, Qinzhan Lin, Fuhua Lu, Xiuqing Wu, Rui Guo, Chuan Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
nanoparticles
chronic kidney disease
emodin
gut microbiota
irrigation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.606227/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.606227/full

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