Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes.

Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes.

Formation of female gametes requires acentriolar spindle assembly during meiosis. Mitotic spindles organize from centrosomes and via local activation of the RanGTPase on chromosomes. Vertebrate oocytes present a RanGTP gradient centred on chromatin at all stages of meiotic maturation. However, this...

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Bibliographic Details
Main Authors: Stéphane Brunet, Julien Dumont, Karen W Lee, Kazuhisa Kinoshita, Pascale Hikal, Oliver J Gruss, Bernard Maro, Marie-Hélène Verlhac
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2556383?pdf=render

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http://europepmc.org/articles/PMC2556383?pdf=render

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