Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity.

Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity.

Retnla (Resistin-like molecule alpha/FIZZ1) is induced during Th2 cytokine immune responses. However, the role of Retnla in Th2-type immunity is unknown. Here, using Retnla(-/-) mice and three distinct helminth models, we show that Retnla functions as a negative regulator of Th2 responses. Pulmonary...

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Bibliographic Details
Main Authors: John T Pesce, Thirumalai R Ramalingam, Mark S Wilson, Margaret M Mentink-Kane, Robert W Thompson, Allen W Cheever, Joseph F Urban, Thomas A Wynn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2663845?pdf=render

Internet

http://europepmc.org/articles/PMC2663845?pdf=render

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