Apolipoprotein E2 (Arg136 → Cys) mutation in the receptor binding domain of apoE is not associated with dominant type III hyperlipoproteinemia1

Apolipoprotein E2 (Arg136 → Cys) mutation in the receptor binding domain of apoE is not associated with dominant type III hyperlipoproteinemia1

Using apoE phenotyping by immunoblotting and apoE genotyping we identified four heterozygous carriers of a rare apolipoprotein (apo) E2 variant, apoE2 (Arg136 → Cys). ApoE2 (Arg136 → Cys) was not distinct from apoE2 (Arg158 → Cys) by phenotyping, but produced a unique pattern of bands on CfoI restri...

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Bibliographic Details
Main Authors: Winfried März, Michael M. Hoffmann, Hubert Scharnagl, Eva Fisher, Minchun Chen, Markus Nauck, Giso Feussner, Heinrich Wieland
Format: Article
Language:English
Published: Elsevier 1998-03-01
Series:Journal of Lipid Research
Subjects:
very low density lipoproteins
apolipoprotein B
low density lipoprotein receptor
hypercholesterolemia
hypertriglyceridemia
dysbetalipoproteinemia
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520333034

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http://www.sciencedirect.com/science/article/pii/S0022227520333034

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