AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

Loss of epithelial polarity impacts organ development and function; it is also oncogenic. AMPK, a key sensor of metabolic stress stabilizes cell-cell junctions and maintains epithelial polarity; its activation by Metformin protects the epithelial barrier against stress and suppresses tumorigenesis....

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Bibliographic Details
Main Authors: Nicolas Aznar, Arjun Patel, Cristina C Rohena, Ying Dunkel, Linda P Joosen, Vanessa Taupin, Irina Kufareva, Marilyn G Farquhar, Pradipta Ghosh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
Metformin, AMPK
epithelial cell polarity
tight junctions
energetic stress
ccdc88a/GIRDIN
Colon cancer
Online Access:https://elifesciences.org/articles/20795

Internet

https://elifesciences.org/articles/20795

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