Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents

Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents

Inhibitors of Rho kinase (ROCK) have potential therapeutic applicability in a wide range of diseases, such as hypertension, stroke, asthma and glaucoma. In a previous article, we described the lead discovery of DL0805, a new ROCK I inhibitor, showing potent inhibitory activity (IC50 6.7 μM). Herein,...

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Bibliographic Details
Main Authors: Yangyang Yao, Renze Li, Xiaoyu Liu, Feilong Yang, Ying Yang, Xiaoyu Li, Xiang Shi, Tianyi Yuan, Lianhua Fang, Guanhua Du, Xiaozhen Jiao, Ping Xie
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:Molecules
Subjects:
Rho kinase
inhibitor
N-substituted prolinamido indazoles
vasorelaxant
SAR
Online Access:https://www.mdpi.com/1420-3049/22/10/1766

Internet

https://www.mdpi.com/1420-3049/22/10/1766

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