The Targeting of MRE11 or RAD51 Sensitizes Colorectal Cancer Stem Cells to CHK1 Inhibition

The Targeting of MRE11 or RAD51 Sensitizes Colorectal Cancer Stem Cells to CHK1 Inhibition

Cancer stem cells (CSCs) drive not only tumor initiation and expansion, but also therapeutic resistance and tumor relapse. Therefore, CSC eradication is required for effective cancer therapy. In preclinical models, CSCs demonstrated high capability to tolerate even extensive genotoxic stress, includ...

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Bibliographic Details
Main Authors: Luca Mattiello, Sara Soliman Abdel Rehim, Martina Musella, Antonella Sistigu, Andrea Guarracino, Sara Vitale, Francesca Corradi, Claudia Galassi, Francesca Sperati, Gwenola Manic, Ruggero De Maria, Ilio Vitale
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
colorectal cancer
chromosomal instability
DNA damage
targeted therapy
tumor-initiating cells
Online Access:https://www.mdpi.com/2072-6694/13/8/1957

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https://www.mdpi.com/2072-6694/13/8/1957

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