The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity

The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity

The degeneration of dopaminergic neurons during Parkinson’s disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in seve...

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Bibliographic Details
Main Authors: Andreas Aufschnaiter, Lukas Habernig, Verena Kohler, Jutta Diessl, Didac Carmona-Gutierrez, Tobias Eisenberg, Walter Keller, Sabrina Büttner
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
α-synuclein
Parkinson’s disease
cathepsin D
Pep4
calcineurin
cytosolic acidification
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00207/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00207/full

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