Drug crystal growth in ternary amorphous solid dispersions: Effect of surfactants and polymeric matrix-carriers

The present study evaluates the crystal growth rate of amorphous drugs when dispersed in different ternary polymeric amorphous solid dispersions (ASDs) in the presence of surfactants. Specifically, ternary ASDs of aprepitant (APT, selected as a model drug) were prepared via melt-quench cooling by ev...

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Bibliographic Details
Main Authors: Afroditi Kapourani, Theodora Tzakri, Vasiliki Valkanioti, Konstantinos N. Kontogiannopoulos, Panagiotis Barmpalexis
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156721000153