Altered Ca2+ Homeostasis and Endoplasmic Reticulum Stress in Myotonic Dystrophy Type 1 Muscle Cells

Altered Ca2+ Homeostasis and Endoplasmic Reticulum Stress in Myotonic Dystrophy Type 1 Muscle Cells

The pathogenesis of Myotonic Dystrophy type 1 (DM1) is linked to unstable CTG repeats in the DMPK gene which induce the mis-splicing to fetal/neonatal isoforms of many transcripts, including those involved in cellular Ca2+ homeostasis. Here we monitored the splicing of three genes encoding for Ca2+...

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Bibliographic Details
Main Authors: Gyorgy Szabadkai, Boris Pantic, Matteo Suman, Giulia Del Moro, Adriana Malena, Emanuele Loro, Annalisa Botta, Lodovica Vergani
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Genes
Subjects:
myotonic dystrophy
muscle cells
Ca2+ homeostasis
SERCA
Ryr1
Cav1.1
ER stress
Online Access:http://www.mdpi.com/2073-4425/4/2/275

Internet

http://www.mdpi.com/2073-4425/4/2/275

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