Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks.

Cyclic dimeric GMP (c-di-GMP) is a bacterial second messenger that modulates many biological processes. Although its role in bacterial pathogenesis during mammalian infection has been documented, the role of c-di-GMP in a pathogen's life cycle within a vector host is less understood. The enzoot...

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Bibliographic Details
Main Authors: Ming He, Zhiming Ouyang, Bryan Troxell, Haijun Xu, Akira Moh, Joseph Piesman, Michael V Norgard, Mark Gomelsky, X Frank Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3128128?pdf=render