Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

Long‐lived macrophage reprogramming drives spike protein‐mediated inflammasome activation in COVID‐19

Abstract Innate immunity triggers responsible for viral control or hyperinflammation in COVID‐19 are largely unknown. Here we show that the SARS‐CoV‐2 spike protein (S‐protein) primes inflammasome formation and release of mature interleukin‐1β (IL‐1β) in macrophages derived from COVID‐19 patients bu...

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Bibliographic Details
Main Authors: Sebastian J Theobald, Alexander Simonis, Theodoros Georgomanolis, Christoph Kreer, Matthias Zehner, Hannah S Eisfeld, Marie‐Christine Albert, Jason Chhen, Susanne Motameny, Florian Erger, Julia Fischer, Jakob J Malin, Jessica Gräb, Sandra Winter, Andromachi Pouikli, Friederike David, Boris Böll, Philipp Koehler, Kanika Vanshylla, Henning Gruell, Isabelle Suárez, Michael Hallek, Gerd Fätkenheuer, Norma Jung, Oliver A Cornely, Clara Lehmann, Peter Tessarz, Janine Altmüller, Peter Nürnberg, Hamid Kashkar, Florian Klein, Manuel Koch, Jan Rybniker
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:EMBO Molecular Medicine
Subjects:
inflammasome
innate immunity
macrophage
NLRP3
SARS‐CoV‐2
Online Access:https://doi.org/10.15252/emmm.202114150

Internet

https://doi.org/10.15252/emmm.202114150

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