Preclinical characterization of the JAK/STAT inhibitor SGI-1252 on skeletal muscle function, morphology, and satellite cell content.

Preclinical characterization of the JAK/STAT inhibitor SGI-1252 on skeletal muscle function, morphology, and satellite cell content.

BACKGROUND:Recent studies have highlighted the JAK/STAT signaling pathway in the regulation of muscle satellite cell behavior. Herein we report preclinical studies designed to characterize the effects of a novel JAK/STAT inhibitor on plantar flexor skeletal muscle function, morphology, and satellite...

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Bibliographic Details
Main Authors: Jacob R Sorensen, Jordan D Fuqua, Michael R Deyhle, Jacob Parmley, Caitlin Skousen, Chad Hancock, Allen C Parcell, Robert D Hyldahl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5999283?pdf=render

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http://europepmc.org/articles/PMC5999283?pdf=render

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