Interferon‐regulated suprabasin is essential for stress‐induced stem‐like cell conversion and therapy resistance of human malignancies

Interferon‐regulated suprabasin is essential for stress‐induced stem‐like cell conversion and therapy resistance of human malignancies

Radiation and chemotherapy represent standard‐of‐care cancer treatments. However, most patients eventually experience tumour recurrence, treatment failure and metastatic dissemination with fatal consequences. To elucidate the molecular mechanisms of resistance to radio‐ and chemotherapy, we exposed...

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Bibliographic Details
Main Authors: Sona Hubackova, Miroslav Pribyl, Lenka Kyjacova, Alena Moudra, Rastislav Dzijak, Barbora Salovska, Hynek Strnad, Vojtech Tambor, Terezie Imrichova, Jiri Svec, Pavel Vodicka, Radka Vaclavikova, Lukas Rob, Jiri Bartek, Zdenek Hodny
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Molecular Oncology
Subjects:
5‐azacytidine
cancer stem‐like cells
interferon response
suprabasin
therapy‐resistance
Online Access:https://doi.org/10.1002/1878-0261.12480

Internet

https://doi.org/10.1002/1878-0261.12480

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