Quality control mechanisms of protein biogenesis: proteostasis dies hard

Quality control mechanisms of protein biogenesis: proteostasis dies hard

The biosynthesis of proteins entails a complex series of chemical reactions that transform the information stored in the nucleic acid sequence into a polypeptide chain that needs to properly fold and reach its functional location in or outside the cell. It is of no surprise that errors might occur t...

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Bibliographic Details
Main Authors: Timothy Jan Bergmann, Giorgia Brambilla Pisoni, Maurizio Molinari
Format: Article
Language:English
Published: AIMS Press 2016-10-01
Series:AIMS Biophysics
Subjects:
protein synthesis
translation
folding
quality control
ER-associated degradation (ERAD)
autophagy
unfolded protein response (UPR)
central dogma
CAT-tails
proteostasis
conformational (protein misfolding) diseases
chemical and pharmacological chaperones
Online Access:http://www.aimspress.com/biophysics/article/1042/fulltext.html

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