LncRNA LINC00525 suppresses p21 expression via mRNA decay and triplex‐mediated changes in chromatin structure in lung adenocarcinoma

LncRNA LINC00525 suppresses p21 expression via mRNA decay and triplex‐mediated changes in chromatin structure in lung adenocarcinoma

Abstract Background Emerging evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in various cancers. In the present study, we aim to investigate the function and molecular mechanism of an up‐regulated and survival‐associated lncRNA, LINC00525, in lung adenocarcinoma (LUAD). Metho...

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Bibliographic Details
Main Authors: Panqi Fang, Hao Chen, Zhifei Ma, Chencheng Han, Wenda Yin, Siwei Wang, Hongyu Zhu, Wenjia Xia, Jie Wang, Lin Xu, Tongyan Liu, Rong Yin
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Cancer Communications
Subjects:
lung adenocarcinoma
LINC00525
p21
mRNA decay
RNA‐DNA triplex
Online Access:https://doi.org/10.1002/cac2.12181

Internet

https://doi.org/10.1002/cac2.12181

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