Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

Age is a recognized risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive loss of motor neurons and neuroinflammation. A hallmark of aging is the accumulation of senescent cells. Yet, the pathogenic role of cellular senescence in ALS remains poorly und...

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Bibliographic Details
Main Authors: Emiliano Trias, Pamela R. Beilby, Mariángeles Kovacs, Sofía Ibarburu, Valentina Varela, Romina Barreto-Núñez, Samuel C. Bradford, Joseph S. Beckman, Luis Barbeito
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
microglia
ALS
senescence
astrocytes
motor neurons
aging
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00042/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00042/full

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