Ontology of the apelinergic system in mouse pancreas during pregnancy and relationship with β-cell mass

Abstract The apelin receptor (Aplnr) and its ligands, Apelin and Apela, contribute to metabolic control. The insulin resistance associated with pregnancy is accommodated by an expansion of pancreatic β-cell mass (BCM) and increased insulin secretion, involving the proliferation of insulin-expressing...

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Bibliographic Details
Main Authors: Brenda Strutt, Sandra Szlapinski, Thineesha Gnaneswaran, Sarah Donegan, Jessica Hill, Jamie Bennett, David J. Hill
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94725-0