The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide

The level of ascorbate peroxidase is enhanced in benznidazole-resistant populations of Trypanosoma cruzi and its expression is modulated by stress generated by hydrogen peroxide

Ascorbate peroxidases (APX) are class I heme-containing enzymes that convert hydrogen peroxide into water molecules. The gene encoding APX has been characterized in 11 strains of Trypanosoma cruzi that are sensitive or resistant to benznidazole (BZ). Bioinformatic analysis revealed the presence of t...

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Bibliographic Details
Main Authors: Fernanda Barbosa Nogueira, Joyce Fernanda A Rodrigues, Marcos Messias S Correa, Jerônimo Conceição Ruiz, Alvaro José Romanha, Silvane Maria Fonseca Murta
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2012-06-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Trypanosoma cruzi
drug resistance
ascorbate peroxidase
hydrogen peroxide
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000400009&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000400009&lng=en&tlng=en

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