De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly

De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly

Vertebrate centrioles normally propagate through duplication, but in the absence of preexisting centrioles, de novo synthesis can occur. Consistently, centriole formation is thought to strictly rely on self-assembly, involving self-oligomerization of the centriolar protein SAS-6. Here, through recon...

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Bibliographic Details
Main Authors: Won-Jing Wang, Devrim Acehan, Chien-Han Kao, Wann-Neng Jane, Kunihiro Uryu, Meng-Fu Bryan Tsou
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
centriole
SAS-6
self-assembly
cartwheel
cilia
centrosome
Online Access:https://elifesciences.org/articles/10586

Internet

https://elifesciences.org/articles/10586

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