Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals

Molecular Mechanisms for the Adaptive Switching Between the OAS/RNase L and OASL/RIG-I Pathways in Birds and Mammals

Host cells develop the OAS/RNase L [2′–5′–oligoadenylate synthetase (OAS)/ribonuclease L] system to degrade cellular and viral RNA, and/or the OASL/RIG-I (2′–5′–OAS like/retinoic acid inducible protein I) system to enhance RIG-I-mediated IFN induction, thus providing the first line of defense agains...

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Bibliographic Details
Main Authors: Enguang Rong, Xiaoxue Wang, Hualan Chen, Chenghuai Yang, Jiaxiang Hu, Wenjie Liu, Zeng Wang, Xiaoyun Chen, Haixue Zheng, Juan Pu, Honglei Sun, Jacqueline Smith, David W. Burt, Jinhua Liu, Ning Li, Yinhua Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
birds
mammals
OASL
OAS/RNase L pathway
OASL/RIG-I pathway
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01398/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01398/full

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