Pathophysiological Roles of Endothelin Receptors in Cardiovascular Diseases

Endothelin (ET)-1 derived from endothelial cells has a much more important role in cardiovascular system regulation than the ET-2 and ET-3 isoforms. Numerous lines of evidence indicate that ET-1 possesses a number of biological activities leading to cardiovascular diseases (CVD) including hypertensi...

Full description

Bibliographic Details
Main Authors: Mamoru Ohkita, Masashi Tawa, Kento Kitada, Yasuo Matsumura
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319304748