Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease

Chronic Low Dose Oral Exposure to Microcystin-LR Exacerbates Hepatic Injury in a Murine Model of Non-Alcoholic Fatty Liver Disease

Microcystins are potent hepatotoxins that have become a global health concern in recent years. Their actions in at-risk populations with pre-existing liver disease is unknown. We tested the hypothesis that the No Observed Adverse Effect Level (NOAEL) of Microcystin-LR (MC-LR) established in healthy...

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Bibliographic Details
Main Authors: Apurva Lad, Robin C. Su, Joshua D. Breidenbach, Paul M. Stemmer, Nicholas J. Carruthers, Nayeli K. Sanchez, Fatimah K. Khalaf, Shungang Zhang, Andrew L. Kleinhenz, Prabhatchandra Dube, Chrysan J. Mohammed, Judy A. Westrick, Erin L. Crawford, Dilrukshika Palagama, David Baliu-Rodriguez, Dragan Isailovic, Bruce Levison, Nikolai Modyanov, Amira F. Gohara, Deepak Malhotra, Steven T. Haller, David J. Kennedy
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Toxins
Subjects:
Microcystin-LR
Non-alcoholic Fatty Liver Disease
No Observed Adverse Effect Level
Lepr<sup>db</sup>/J mice
hepatotoxicity
oxidative stress
TiO<sub>2</sub> enriched phosphopeptides
Online Access:https://www.mdpi.com/2072-6651/11/9/486

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https://www.mdpi.com/2072-6651/11/9/486

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