Identifying the major lactate transporter of Toxoplasma gondii tachyzoites

Abstract Toxoplasma gondii and Plasmodium falciparum parasites both extrude l-lactate, a byproduct of glycolysis. The P. falciparum Formate Nitrite Transporter, PfFNT, mediates l-lactate transport across the plasma membrane of P. falciparum parasites and has been validated as a drug target. The T. g...

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Bibliographic Details
Main Authors: Joy M. Zeng, Sanduni V. Hapuarachchi, Sarah H. Shafik, Rowena E. Martin, Kiaran Kirk, Giel G. van Dooren, Adele M. Lehane
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-86204-3