Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts.

Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts.

The Notch ligand Delta-like 4 (Dll4) is highly expressed in vascular endothelium and has been shown to play a pivotal role in regulating tumor angiogenesis. Blockade of the Dll4-Notch pathway in preclinical cancer models has been associated with non-productive angiogenesis and reduced tumor growth....

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Main Authors: Kiersten Marie Miles, Mukund Seshadri, Eric Ciamporcero, Remi Adelaiye, Bryan Gillard, Paula Sotomayor, Kristopher Attwood, Li Shen, Dylan Conroy, Frank Kuhnert, Alshad S Lalani, Gavin Thurston, Roberto Pili
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4231048?pdf=render

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http://europepmc.org/articles/PMC4231048?pdf=render

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