Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development

Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development

Brucella spp. are facultative intracellular Gram negative bacteria with specific tropism for monocytes/macrophages. Clinical manifestations of brucellosis are primarily immune-mediated and not thought to be due to bacterial virulence factors. Acquired immunity to brucellosis has been studied throug...

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Bibliographic Details
Main Authors: Anthony P Cannella, Renee M Tsolis, Li eLiang, Philip eFelgner, Mayuko eSaito, Eduardo eGotuzzo, Alessandro eSette, Joseph M Vinetz
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Brucella
Systems Biology
immunology
zoonotic diseases
T cell epitope
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00001/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00001/full

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