Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms?

Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms?

Alzheimer’s disease (AD) is characterized by proteasome activity impairment, oxidative stress, and epigenetic changes, resulting in β-amyloid (Aβ) production/degradation imbalance. Apolipoprotein E (ApoE) is implicated in Aβ clearance, and particularly, the ApoE ε4 isoform predisposes to AD developm...

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Bibliographic Details
Main Authors: Rebecca Piccarducci, Simona Daniele, Beatrice Polini, Sara Carpi, Lucia Chico, Jonathan Fusi, Filippo Baldacci, Gabriele Siciliano, Ubaldo Bonuccelli, Paola Nieri, Claudia Martini, Ferdinando Franzoni
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2021/8869849

Internet

http://dx.doi.org/10.1155/2021/8869849

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