Metformin exerts anti-cancerogenic effects and reverses epithelial-to-mesenchymal transition trait in primary human intrahepatic cholangiocarcinoma cells

Metformin exerts anti-cancerogenic effects and reverses epithelial-to-mesenchymal transition trait in primary human intrahepatic cholangiocarcinoma cells

Abstract Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive cancer with marked resistance to chemotherapeutics without therapies. The tumour microenvironment of iCCA is enriched of Cancer-Stem-Cells expressing Epithelial-to-Mesenchymal Transition (EMT) traits, being these features associa...

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Bibliographic Details
Main Authors: Sabina Di Matteo, Lorenzo Nevi, Diletta Overi, Nadine Landolina, Jessica Faccioli, Federico Giulitti, Chiara Napoletano, Andrea Oddi, Augusto M. Marziani, Daniele Costantini, Agostino M. De Rose, Fabio Melandro, Maria C. Bragazzi, Gian Luca Grazi, Pasquale B. Berloco, Felice Giuliante, Giuseppe Donato, Lorenzo Moretta, Guido Carpino, Vincenzo Cardinale, Eugenio Gaudio, Domenico Alvaro
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81172-0

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https://doi.org/10.1038/s41598-021-81172-0

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