Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice

Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice

The acetyltransferase MYST1 stimulated by acetyl-CoA, and the deacetylase SIRT2 stimulated by NAD+, regulate PAX7 acetylation in muscle stem cells, which in turn, regulates stem cell self-renewal and regeneration following injury in mouse skeletal muscle.

Bibliographic Details
Main Authors: Marie-Claude Sincennes, Caroline E. Brun, Alexander Y. T. Lin, Tabitha Rosembert, David Datzkiw, John Saber, Hong Ming, Yoh-ichi Kawabe, Michael A. Rudnicki
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23577-z

Internet

https://doi.org/10.1038/s41467-021-23577-z

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