Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9

Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9

Iron is vital for many homeostatic processes, and its liberation from ferritin nanocages occurs in the lysosome. Studies indicate that ferritin and its binding partner nuclear receptor coactivator-4 (NCOA4) are targeted to lysosomes by a form of selective autophagy. By using genome-scale functional...

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Bibliographic Details
Main Authors: Jonathan M. Goodwin, William E. Dowdle, Rowena DeJesus, Zuncai Wang, Philip Bergman, Marek Kobylarz, Alicia Lindeman, Ramnik J. Xavier, Gregory McAllister, Beat Nyfeler, Gregory Hoffman, Leon O. Murphy
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
NCOA4
ferritinophagy
autophagy
ULK1/2
TBK1
ALS
TAX1BP1
ATG9A
pooled CRISPR screen
trafficking
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717311415

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http://www.sciencedirect.com/science/article/pii/S2211124717311415

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