Whole Genome DNA Methylation Analysis of Active Pulmonary Tuberculosis Disease Identifies Novel Epigenotypes: <i>PARP9</i>/<i>miR-505</i>/<i>RASGRP4</i>/<i>GNG12</i> Gene Methylation and Clinical Phenotypes

Whole Genome DNA Methylation Analysis of Active Pulmonary Tuberculosis Disease Identifies Novel Epigenotypes: <i>PARP9</i>/<i>miR-505</i>/<i>RASGRP4</i>/<i>GNG12</i> Gene Methylation and Clinical Phenotypes

We hypothesized that DNA methylation patterns may contribute to the development of active pulmonary tuberculosis (TB). Illumina’s DNA methylation 450 K assay was used to identify differentially methylated loci (DML) in a discovery cohort of 12 active pulmonary TB patients and 6 healthy subjects (HS)...

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Bibliographic Details
Main Authors: Yung-Che Chen, Chang-Chun Hsiao, Ting-Wen Chen, Chao-Chien Wu, Tung-Ying Chao, Sum-Yee Leung, Hock-Liew Eng, Chiu-Ping Lee, Ting-Ya Wang, Meng-Chih Lin
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
pulmonary TB
whole genome DNA methylation
<i>PARP9</i>
<i>miR505</i>
<i>RASGRP4</i>
<i>GNG12</i>
Online Access:https://www.mdpi.com/1422-0067/21/9/3180

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https://www.mdpi.com/1422-0067/21/9/3180

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