Hypoxia increases mutational load of breast cancer cells through frameshift mutations

Hypoxia increases mutational load of breast cancer cells through frameshift mutations

Tumor hypoxia-induced downregulation of DNA repair pathways and enhanced replication stress are potential sources of genomic instability. A plethora of genetic changes such as point mutations, large deletions and duplications, microsatellite and chromosomal instability have been discovered in cells...

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Bibliographic Details
Main Authors: Goutham Hassan Venkatesh, Pamela Bravo, Walid Shaaban Moustafa Elsayed, Francis Amirtharaj, Bartosz Wojtas, Raefa Abou Khouzam, Husam Hussein Nawafleh, Sandeep Mallya, Kapaettu Satyamoorthy, Philippe Dessen, Filippo Rosselli, Jerome Thiery, Salem Chouaib
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
hypoxia
dna repair
mutational burden
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1750750

Internet

http://dx.doi.org/10.1080/2162402X.2020.1750750

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