Proteomic profiling of Plasmodium sporozoite maturation identifies new proteins essential for parasite development and infectivity.
Plasmodium falciparum sporozoites that develop and mature inside an Anopheles mosquito initiate a malaria infection in humans. Here we report the first proteomic comparison of different parasite stages from the mosquito -- early and late oocysts containing midgut sporozoites, and the mature, infecti...
Main Authors: | Edwin Lasonder, Chris J Janse, Geert-Jan van Gemert, Gunnar R Mair, Adriaan M W Vermunt, Bruno G Douradinha, Vera van Noort, Martijn A Huynen, Adrian J F Luty, Hans Kroeze, Shahid M Khan, Robert W Sauerwein, Andrew P Waters, Matthias Mann, Hendrik G Stunnenberg |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-10-01
|
Series: | PLoS Pathogens |
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18974882/pdf/?tool=EBI |
Similar Items
-
Long term protection after immunization with P. berghei sporozoites correlates with sustained IFNγ responses of hepatic CD8+ memory T cells.
by: Krystelle Nganou-Makamdop, et al.
Published: (2012-01-01) -
Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites.
by: Remko Schats, et al.
Published: (2015-01-01) -
A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes, Sporozoites, and Liver-Stages
by: Catherin Marin-Mogollon, et al.
Published: (2019-04-01) -
A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites
by: Ben C L van Schaijk, et al.
Published: (2014-11-01) -
Transition of Plasmodium sporozoites into liver stage-like forms is regulated by the RNA binding protein Pumilio.
by: Carina S S Gomes-Santos, et al.
Published: (2011-05-01)