Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation

Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation

Transcription initiation by RNA polymerase III requires TFIIIB, a complex formed by Brf1/Brf2, TBP and Bdp1. Here, the authors describe the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter and characterize the role of Bdp1 in TFIIIB assembly and pre-initiation complex formation.

Bibliographic Details
Main Authors: Jerome Gouge, Nicolas Guthertz, Kevin Kramm, Oleksandr Dergai, Guillermo Abascal-Palacios, Karishma Satia, Pascal Cousin, Nouria Hernandez, Dina Grohmann, Alessandro Vannini
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00126-1

Internet

https://doi.org/10.1038/s41467-017-00126-1

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