Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation

Transcription initiation by RNA polymerase III requires TFIIIB, a complex formed by Brf1/Brf2, TBP and Bdp1. Here, the authors describe the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter and characterize the role of Bdp1 in TFIIIB assembly and pre-initiation complex formation.

Bibliographic Details
Main Authors:	Jerome Gouge, Nicolas Guthertz, Kevin Kramm, Oleksandr Dergai, Guillermo Abascal-Palacios, Karishma Satia, Pascal Cousin, Nouria Hernandez, Dina Grohmann, Alessandro Vannini
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00126-1

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spelling	doaj-24b5aabdb8694c1e890901d3aeef0ee92021-01-31T12:30:40ZengNature Publishing GroupNature Communications2041-17232017-07-018111110.1038/s41467-017-00126-1Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiationJerome Gouge0Nicolas Guthertz1Kevin Kramm2Oleksandr Dergai3Guillermo Abascal-Palacios4Karishma Satia5Pascal Cousin6Nouria Hernandez7Dina Grohmann8Alessandro Vannini9The Institute of Cancer ResearchThe Institute of Cancer ResearchDepartment of Biochemistry, Genetics and Microbiology, Institute of Microbiology, University of RegensburgCenter for Integrative Genomics, Faculty of Biology and Medicine, University of LausanneThe Institute of Cancer ResearchThe Institute of Cancer ResearchCenter for Integrative Genomics, Faculty of Biology and Medicine, University of LausanneCenter for Integrative Genomics, Faculty of Biology and Medicine, University of LausanneDepartment of Biochemistry, Genetics and Microbiology, Institute of Microbiology, University of RegensburgThe Institute of Cancer ResearchTranscription initiation by RNA polymerase III requires TFIIIB, a complex formed by Brf1/Brf2, TBP and Bdp1. Here, the authors describe the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter and characterize the role of Bdp1 in TFIIIB assembly and pre-initiation complex formation.https://doi.org/10.1038/s41467-017-00126-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jerome Gouge Nicolas Guthertz Kevin Kramm Oleksandr Dergai Guillermo Abascal-Palacios Karishma Satia Pascal Cousin Nouria Hernandez Dina Grohmann Alessandro Vannini
spellingShingle	Jerome Gouge Nicolas Guthertz Kevin Kramm Oleksandr Dergai Guillermo Abascal-Palacios Karishma Satia Pascal Cousin Nouria Hernandez Dina Grohmann Alessandro Vannini Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation Nature Communications
author_facet	Jerome Gouge Nicolas Guthertz Kevin Kramm Oleksandr Dergai Guillermo Abascal-Palacios Karishma Satia Pascal Cousin Nouria Hernandez Dina Grohmann Alessandro Vannini
author_sort	Jerome Gouge
title	Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation
title_short	Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation
title_full	Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation
title_fullStr	Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation
title_full_unstemmed	Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation
title_sort	molecular mechanisms of bdp1 in tfiiib assembly and rna polymerase iii transcription initiation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-07-01
description	Transcription initiation by RNA polymerase III requires TFIIIB, a complex formed by Brf1/Brf2, TBP and Bdp1. Here, the authors describe the crystal structure of a Brf2-TBP-Bdp1 complex bound to a DNA promoter and characterize the role of Bdp1 in TFIIIB assembly and pre-initiation complex formation.
url	https://doi.org/10.1038/s41467-017-00126-1
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Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation

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