Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

Hepatitis B Virus X Protein Promotes Degradation of SMC5/6 to Enhance HBV Replication

The hepatitis B virus (HBV) regulatory protein X (HBx) activates gene expression from the HBV covalently closed circular DNA (cccDNA) genome. Interaction of HBx with the DDB1-CUL4-ROC1 (CRL4) E3 ligase is critical for this function. Using substrate-trapping proteomics, we identified the structural m...

Full description

Bibliographic Details
Main Authors: Christopher M. Murphy, Yanping Xu, Feng Li, Kouki Nio, Natalia Reszka-Blanco, Xiaodong Li, Yaxu Wu, Yanbao Yu, Yue Xiong, Lishan Su
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716310907

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716310907

Similar Items