Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell Death

Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell Death

Neurotrophins (NTs) are secretory proteins that bind to target receptors and influence many cellular functions, such as cell survival and cell death in neurons. The mammalian NT brain-derived neurotrophic factor (matBDNF) is the C-terminal mature form released by cleavage from the proBDNF precursor....

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Bibliographic Details
Main Authors: Laura Ester Montroull, Víctor Danelon, Andrea Beatriz Cragnolini, Daniel Hugo Mascó
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
matBDNF
proBDNF
TrkB
p75NTR
hippocampus
seizures
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00004/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00004/full

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