Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo

Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo

Diosbulbin B (DIOB), a hepatotoxic furan-containing compound, is a primary ingredient in Dioscorea bulbifera L., a common herbal medicine. Metabolic activation is required for DIOB-induced liver injury. Protein covalent binding of an electrophilic reactive intermediate of DIOB is considered to be on...

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Bibliographic Details
Main Authors: Kai Wang, Dongju Lin, Xiucai Guo, Wenlin Huang, Jiang Zheng, Ying Peng
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Toxins
Subjects:
diosbulbin B
hepatotoxicity
protein covalent binding
metabolic activation
bromine-based analytical technique
Online Access:https://www.mdpi.com/2072-6651/9/8/249

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https://www.mdpi.com/2072-6651/9/8/249

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