Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice

Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice

Hypothalamic oxytocin (OT) is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that the intracellular free calcium concentration ([Ca2+]i) that seems to trigger OT release can be elevated by -NAD+, cADPR, and ADP in mouse oxytocine...

Full description

Bibliographic Details
Main Authors: Jing Zhong, Sarwat Amina, Mingkun Liang, Shirin Akther, Teruko Yuhi, Tomoko Nishimura, Chiharu Higashida, Takahiro Tsuji, Hong-Xiang Liu, Minako Hashii, Kazumi Furuhara, Shigeru Yokoyama, Yasuhiko Yamamoto, Hiroshi Okamoto, Yong Juan Zhao, Hon Cheung Lee, Makoto Tominaga, Olga Lopatina, Haruhiro Higashida
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Neuroscience
Subjects:
Cyclic ADP-Ribose
Oxytocin
stress
hyperthermia
secretion
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00304/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00304/full

Similar Items