The Abrogation of Phosphorylation Plays a Relevant Role in the CCR5 Signalosome Formation with Natural Antibodies to CCR5

The Abrogation of Phosphorylation Plays a Relevant Role in the CCR5 Signalosome Formation with Natural Antibodies to CCR5

The exposure to CCR5 (CC chemokine receptor 5) specific natural antibodies in vitro produces a Class B β-arrestin2-dependent CCR5 retention with the aid of ERK1, due to the formation of a CCR5 signalosome, which remains stable for at least 48 h. Considering that β-arrestins and MAPKs are receptive t...

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Bibliographic Details
Main Authors: Assunta Venuti, Claudia Pastori, Gabriel Siracusano, Rosamaria Pennisi, Agostino Riva, Massimo Tommasino, Maria Teresa Sciortino, Lucia Lopalco
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Viruses
Subjects:
CCR5
anti CCR5 antibodies
CCR5 signalosome
HIV infection
HIV protection
CCR5 based therapy
ESN
LTNP
Online Access:https://www.mdpi.com/1999-4915/10/1/9

Internet

https://www.mdpi.com/1999-4915/10/1/9

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