Non-sterilizing, Infection-Permissive Vaccination With Inactivated Influenza Virus Vaccine Reshapes Subsequent Virus Infection-Induced Protective Heterosubtypic Immunity From Cellular to Humoral Cross-Reactive Immune Responses

Non-sterilizing, Infection-Permissive Vaccination With Inactivated Influenza Virus Vaccine Reshapes Subsequent Virus Infection-Induced Protective Heterosubtypic Immunity From Cellular to Humoral Cross-Reactive Immune Responses

Conventional influenza vaccines aim at the induction of virus-neutralizing antibodies that provide with sterilizing immunity. However, influenza vaccination often confers protection from disease but not from infection. The impact of infection-permissive vaccination on the immune response elicited by...

Full description

Bibliographic Details
Main Authors: Angela Choi, Lorena I. Ibañez, Shirin Strohmeier, Florian Krammer, Adolfo García-Sastre, Michael Schotsaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
influenza
pre-existing immunity
TIV
alveolar macrophage
tissue-resident memory T cell
germinal center B cell
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01166/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01166/full

Similar Items