The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro.

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro.

The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. Thus, small molecules that interfere with the HuR-ARE interaction c...

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Bibliographic Details
Main Authors: Kawaljit Kaur, Xiaoqing Wu, James K Fields, David K Johnson, Lan Lan, Miranda Pratt, Amber D Somoza, Clay C C Wang, John Karanicolas, Berl R Oakley, Liang Xu, Roberto N De Guzman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5393604?pdf=render

Internet

http://europepmc.org/articles/PMC5393604?pdf=render

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