Esters and amides of 3-R-2,8-dioxo-7,8-dihydro2H-pyrrolo[1,2-a][1,2,4]­triazino[2,3-c]quinazolin-5a(6H)-carboxylic(-propanoic) acids: synthesis and biological activity

Esters and amides of 3-R-2,8-dioxo-7,8-dihydro2H-pyrrolo[1,2-a][1,2,4]­triazino[2,3-c]quinazolin-5a(6H)-carboxylic(-propanoic) acids: synthesis and biological activity

It is known that carboxyl groups bonded to aryl or hetaryl moieties play a role of the “pharmacophore” fragment in most NSAID molecules. It should be mentioned that the carboxyl group may cause the appearance of toxic effects and is characterized by unsatisfactory pharmacokinetic properties. The str...

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Bibliographic Details
Main Authors: Viktor V. Stavytskyi, Inna S. Nosulenko, Kostiantyn I. Kandybey, Oleksii Yu. Voskoboinik, Serhii I. Kovalenko
Format: Article
Language:English
Published: National University of Pharmacy (Kharkiv, Ukraine) 2020-03-01
Series:Журнал органічної та фармацевтичної хімії
Subjects:
esters
amides
synthesis
radical scavenging activity
lox-inhibiting activity
pyrrolo[1
2-а][1
2
4]triazino[2
Online Access:http://ophcj.nuph.edu.ua/article/view/ophcj.20.192826/198319

Internet

http://ophcj.nuph.edu.ua/article/view/ophcj.20.192826/198319

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