Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue

Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue

Ischemic stroke causes cellular alterations in the “neurovascular unit” (NVU) comprising neurons, glia, and the vasculature, and affects the blood-brain barrier (BBB) with adjacent extracellular matrix (ECM). Limited data are available for the zone between the NVU and ECM that has not yet considered...

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Bibliographic Details
Main Authors: Dominik Michalski, Emma Spielvogel, Joana Puchta, Willi Reimann, Henryk Barthel, Björn Nitzsche, Bianca Mages, Carsten Jäger, Henrik Martens, Anja K. E. Horn, Stefan Schob, Wolfgang Härtig
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Physiology
Subjects:
stroke
fibronectin
collagen IV
basement membrane
blood-brain barrier
extracellular matrix
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.575598/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.575598/full

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