Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling

Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling

Wnt signaling is known to regulate the formation of the blood-brain barrier. Here Hübner et al. dissect the underlying mechanisms using high resolution live imaging in zebrafish, and find that Wnt regulates anastomosis of angiogenic sprouts in the brain by counteracting sphingosine-1-phosphate recep...

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Bibliographic Details
Main Authors: Kathleen Hübner, Pauline Cabochette, Rodrigo Diéguez-Hurtado, Cora Wiesner, Yuki Wakayama, Kathrin S. Grassme, Marvin Hubert, Stefan Guenther, Heinz-Georg Belting, Markus Affolter, Ralf H. Adams, Benoit Vanhollebeke, Wiebke Herzog
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07302-x

Internet

https://doi.org/10.1038/s41467-018-07302-x

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